Investigation of the Composition of the Substance of Antibacterial Preparation Bismoverol Obtained by Precipitation of Bismuth (III) Tartrates from the Solutions of Acids
E. V. TIMAKOVA, O. A. LOGUTENKO, V. I. EVSEENKO, A. S. MIKHAILOVA, and YU. M. YUKHIN
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Ul. Kutateladze 18, Novosibirsk 630128 (Russia)
Keywords: препараты висмута, осаждение из растворов, тартраты висмута, бактериальные инфекции, рентгенофазовый анализ, ИК- КР-спектры, bismuth preparations, precipitation from solutions, bismuth tartrates, bacterial infections, X-ray phase analysis, IR and Raman spectra
Abstract
Precipitation of bismuth (III) tartrates from hydrochloric, nitric and acetic solutions depending on the concentration of tartrate ions and process temperature was studied by means of chemical, X-ray phase, differential thermal analysis, IR and Raman spectroscopy, and electron microscopy. It was demonstrated that normal bismuth tartrate with the composition BiC4H3O6 x H2O or bismuth tartratahydrotartrate trihydrate with the composition [Bi(C4H4O6)(C4H5O6)] x 3H2O are formed after the addition of tartaric acid into hydrochloric and acetic solutions of bismuth. Two compounds are formed during bismuth precipitation from nitric solutions with tartaric acid, depending on the concentration of tartrate ions: nitrate-tartrate complex with the composition [Bi(NO3)(H2O)3]C4H4O6 and tartratahydrotartreate trihydrate [Bi(C4H4O6)(C4H5O6)] x 3H2O. As a result of multiple washing with water, the nitrate-tartrate complex is transformed into X-ray amorphous normal bismuth tartrate with the composition BiC4H3O6 x H2O. Normal bismuth tartrate is also formed after the addition of sodium tartrate into the nitric solutions of bismuth for the molar ratio of tartrate ions to bismuth equal to 1−3, and process temperature 23−60 °C. With further increase in sodium tartrate concentration in the system, the degree of bismuth precipitatiuon decreases sharply as a consequence of the formation of water-soluble complex ions. It was demonstrated that normal bismuth tartrate BiC4H3O6 x H2O is identical with the compound known previously as monobismuth tartaric acid. It was shown that the hydroxy bismuth salt of monobismuth tartaric acid, which is obtained by precipitation from lactic-acetic solutions and is recommended as the medical substance of antisyphilitic preparation Bismoverol, is not an individual compound but is a mixture of normal bismuth tartrate with the composition BiC4H3O6 x H2O and bismuth oxoacetate with the composition BiОC2H3O2.
|
