Издательство СО РАН

Издательство СО РАН

Адрес Издательства СО РАН: Россия, 630090, а/я 187
Новосибирск, Морской пр., 2

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Поиск по журналу

Журнал структурной химии

2014 год, номер Приложение 2

SYNTHESIS AND CRYSTAL STRUCTURE ANALYSIS OF TWO THIAZOLO[3,2– a]PYRIMIDINE DERIVATIVES

H. Nagarajaiah1, M.I.A. Khazi2, A.Y. Khan2, N. Fathima1, I.A.M. Khazi2, N.S. Begum1
1Bangalore University, Bangalore-560001, India
noorsb05@gmail.com; noorsb@rediffmail.com
2Karnatak University, Dharwad-580003, India
Ключевые слова: thiazolo[3,2–a]pyrimidine derivative, crystal structure, C–H…O and C–H…ПЂ weak interactions
Страницы: 343-348
Подраздел: ОРГАНИЧЕСКАЯ СУПРАМОЛЕКУЛЯРНАЯ ХИМИЯ

Аннотация

Synthesis of 5R*–(3–methoxy–phenyl)–3,7–dimethyl–5H–thiazolo[3,2–a]pyrimidine–2,6–dicarboxylic acid diethyl ester (2a) and 3,7–dimethyl–5S*–thiophen–2–yl–5H–thiazolo[3,2–a]pyrimidine–2,6–dicarboxylic acid diethyl ester (2b) are achieved by the cyclocondensation of 3,4–dihydropyrimidine–2–thione derivative with a-haloester. Preliminary analysis was done spectroscopically by means of 1H NMR spectra, mass spectra and elemental analyses. Further the structures were confirmed by X-ray crystal structure analysis. The two molecules are not identical in configuration. In both the compounds the central pyrimidine ring adopts a conformation which is best described as an intermediate between a boat and screw boat form. The crystal structure is stabilized by intermolecular C–H…O and C–H…π weak interactions.