Solid-Phase Copolymerization of L,D-lactide with Chitosan
T. S. DEMINA1, L. V. VLADIMIROV2, T. A. AKOPOVA1 and A. N. ZELENETSKY1
1Enikolopov Institute of Synthetic Polymer Materials, Russian Academy of Sciences, Ul. Profsoyuznaya 79, Moscow 117393 (Russia)
E-mail: detans@gmail.com
2Semenov Institutes of Chemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119991(Russia)
Keywords: solid-phase synthesis, chitosan, lactide, grafted copolymers, biocompatible materials
Pages: 577–583
Abstract
With the use of solid-phase synthesis in an extruder, chitosan and L,D-lactide grafted copolymers were obtained. A mechanism of graft polymerization was proposed, an effect of process conditions exerted on the yield and structure of the target products was studied. Based on the data obtained from fractionation, IR spectroscopy and study of the elemental composition of the fractions, a substitution level has been calculated for the chitosan amino groups that were 0.19–0.41. An average polymerization level for lactide in grafted chains and an effect exerted by the grafting on the solubility of chitosan and physico mechanical characteristics of film materials were determined. Based on the copolymers synthesized, three-dimensional matrices have been obtained for tissue engineering (macroporous hydrogels, spherical microparticles), as well as compatibility and biodegradation rate have been estimated for the materials.
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