THE POSSIBILITY OF EARLY DETECTION OF ATHEROSCLEROTIC VASCULAR LESIONS IN RHEUMATIC DISEASES
A.N. Bazhenov, A.L. Maslyanskiy, E.P. Kolesova, I.N. Penin, M.D. Cheshuina, A.V. Kozlenok, O.P. Rotar
Keywords: ревматическое заболевание, дисфункция эндотелия, комплекс интима-медиа, атеросклероз, rheumatic disease, endothelial dysfunction, thickness intima-media, atherosclerosis
Abstract
Identification of subclinical lesions of the heart and blood vessels in patients with rheumatic diseases (RD), as well as the comparison of subclinical markers of cardiovascular lesions in patients with RD and RD patients without having one of the risk factors for cardiovascular disease. Surveyed 56 patients (15 men and 41 female) at the age of 45.2 ± 13.42 years with different rheumatic diseases. For the comparison group surveyed residents of one of the districts of Saint Petersburg (50 people). All patients have been conducted questioning, characterizes lifestyle, risk factors, co-morbidity and drug therapy. Anthropometry were measured in weight, height with a calculation of body mass index, waist circumference, hip circumference. Endothelial dysfunction study conducted on the EndoPat 2000 (company “Itamar Medical Ltd, Israel): reactive hyperemia index (RHI) and augmentation index (AI). Dysfunction of the endothelium have registered a value of RHI<1.64. Echocardiography and ultrasonography of carotid arteries with the assessment of the thickness of the thickness intima-media (TIM) conducted by Vivid 7 high resolution sensor 7 MHz. Central pressure values determined on device SphygmoCor (Australia) by applanation tonometry. The speed of pulse wave (SPW) carotid artery, femoral artery measured the sphygmography method on the device SphygmoCor PWX. On an empty stomach identified glucose and lipid levels (Hitachi-902). Average levels of cholesterol, triglycerides, SAD/DAD, BMI in groups not significantly different. Identify correlation titer of antinuclear factor with RHI, p = 0.53; AI (EndoPat), p = 0.47; PP, p = –0.43. Among persons 1 group (systemic sclerosis) frequently detected RHI<1,64 and SPW>9.6 m/s compared to the 2nd and 3rd groups of patients with RD. We have identified correlate titer of antinuclear factor, reactive hyperemia index (RHI), augmentation index (AI, EndoPat), the central pulse pressure (PP) show integration structures of the cardiovascular system in the pathological process in RD, including asymptomatic from the system.
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