Home – Home – Jornals – The journal "Ateroskleroz" 2013 number 2

Aim. To assess an activity of Fas-dependant apoptosis and its links with classical risk factors in patients (pts.) with acute and chronic coronary heart disease (CHD). Material and methods. We scrutinized 126 pts. with CHD: 84 pts. (1st group) - on 10–14th days of myocardial infarction (MI) and 42 pts. (2 ^nd group) with stable CHD. Control group consisted of 77 volunteers without CHD and metabolic syndrome (MS). Serum levels of apoptosis activator sFasL and its inhibitor sFas were measured by ELISA. SPSS for Windows 19.0 was used. Results. The frequency of classical risk factors in 1st and 2nd groups did not differ significantly, both sFas (37.8±24.4 vs. 22.1±9.3 ng/ml, p = 0.021) and sFasL (86.2±24.5 vs. 63.8±22.7 pg/ml, p < 0.001) levels being higher in 2nd group. Besides biomarkers concentrations were higher in 2nd group than in controls. In the whole cohort of CHD pts. we revealed correlations between sFas level and age (ρS = 0.330, p = 0.001), sFas and CC (ρ = –0.591, р < 0.001) and МВ-CC (ρ = –0.484, р < 0.001) levels. The level of sFasL correlated with HDL-С level (ρS = 0.329, p = 0.017) and was higher in arterial hypertension (79.8±31.2 vs. 60.1±24.1 pg/ml, p < 0.001). In the 1st group sFas/sFasL ratio was lower in pts. with full-component MS than in those with 3 components (204.7±43.8 vs. 464.4±196.4, p = 0.024), sFasL level being higher in DM/hyperglycemia. In the same group the number of coronary lesions appeared to be sFasL level predictor (β = 0.28, р = 0.016): F(2,65) = 496, p = 0.001. The pts. survived MI were characterized with higher sFasL level: 85.6±25.4 vs. 73.3±31.4 pg/ml ( p = 0.001). The concentration of sFasL (ρS = –0.362, p < 0.001) and sFas/sFasL (ρS = –0.341, p = 0.007) correlated with post-infarction period duration. Conclusion. Pts. with CHD had higher sFas и sFasL levels in comparison with controls. An activity of Fas-dependant apoptosis was associated with MS, survived MI and coronary lesions confirming its role in CHD development. The levels of sFas and sFasL depended on post-infarction period duration that may be of great significance as to prevent repeated coronary events.