DYSLIPIDAEMIAS IN THE ELDERLY AND THE VERY OLD: GENDER DIFFERENCES
E.V. Tereshina, O.P. Pleteneva, N.E. Osokina, Yu.D. Aprosin, E.P. Zakiev
Keywords: dyslipidaemia, lipoprotein dispersion, aging, gender differences
Abstract
BACKGROUND: Aging of the world population attracts attention to the elucidation of etiology factors triggering development of age-dependent systemic pathologies including atherosclerosis. We assessed the dynamics of lipid parameters changing and their gender differences in people aged 45 years and over. METHODS. Total cholesterol, triglycerides (TG) and relative content of very low density lipoproteins (VLDL) and low density lipoproteins (LDL) in blood serum were measured by means of spectral analyzer and electrophoresis on acetate plates in 1650 patients (1167 women, 483 men) aged 45 yrs and over. The prevalence of dyslipidaemias was estimated by standard statistic methods. RESULTS. In age period over 75 yrs the frequency of dyslipidaemias decreased from 81.0 % to 36,4 %. The most significant decrease concerned combined dyslipidaemia (CD) (4 times) and triglyceridemia (2 times). CD lowering in men observed through the age range of 45–90 yrs, in women – from 75 yrs and over. Frequency of hypercholesterolemia in men increased during 60-90 yrs and decreased in women in the period 45-75 yrs. In CD the relative increase of both VLDL and LDL was observed but the VLDL content elevation is associated with high mortality. CONCLUSION: Frequency of elevated TG and VLDL content in sera significantly decreased in men aged 60 yrs and over and in women aged 75 yrs and over.
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