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The journal "Ateroskleroz"

2011 year, number 1

Interconnection at the level of uric acid and apolipOprotein E in the blood of persons with normal and hyper lipidemia

E.R. Boijko, A.O. Ovechkin, A.M. Kaneva, N.N. Potolitsyna
Keywords: apoE, uric acid, correlation, normolipidemia, hyperlipidemia
Pages: 26-30


To investigate the levels of uric acid and apoE in patients with normo- and hyperlipidemia. The serum lipids, apolipoproteins and uric acid levels were measured with Chronolab (Switzerland) kits in 78 patients: 53 patients with normolipidemia and 25 patients with hyperlipidemia of type IIa and IIb. Significantly higher levels of apo-E were registered in patients with hyperlipidemia than in patients with normolipidemia, but there were no differences in content of uric acid. A comparative correlation analysis detected a significant correlation between uric acid and apoE levels in both groups but in normolipidemic patients the correlation was positive while in hyperlipidemic patients it was negative. Hyperlipidemia provokes inversion of correlation between the levels of uric acid, apoE and apoC3. A rise of apoC3 may serve an adaptive mechanism of inhibition of apo-E induced hyperlipidemia.