POLYMORPHISM OF GENES OF PREDISPOSITION TO CARDIOVASCULAR DISEASES IN POPULATION AND PROSPECTIVE STUDY
M.I. Voevoda, V.N. Maksimov, S.K. Malujtina, V.V. Gafarov, S.V. Shishkin, A.G. Romaschenko, I.B. Kulikov, S.N. Ustinov, E.V. Shahtshneider, V.P. Kobzev
Pages: 24-28
Abstract
Analysis of polymorphism of genes of predisposition to cardiovascular diseases (CVD) in population and prospective study in Novosibirsk. Within the framework of the program MONICA is observed 7111 men and 5523 women from a unorganized population of Novosibirsk. For detection of the independent factors influential on risk of death from CVD, the multiple logistics regression analysis was conducted. On group of 838 men the association of polymorphism of genes - candidates CVD with the factors of risk, morbidity and death rate from CVD was studied. The data of epidemiological prospective study confirm independent influencing of a heritable predisposition on CVD on death rate from CVD in an opened population of Novosibirsk. The polymorphism of a gene FMS in man's population sample is associated with an stroke (the data of prospective study) and with the factors of risk CVD in population research. I/D polymorphism of genes an ACE and A2b-adrenoreceptor is associated with CVD in a man's population of Novosibirsk. The primary prevention of CVD should actuate a family history and polymorphism of genes - candidates, as the relevant factor for including of groups of risk.
|
