HEMOSTASIS AND LIPID PROFILE FEATURES IN THE NORTH
A.A. Gromov1, M.V. Kruchinina1,2, V.N. Kruchinin3
1Research Institute of Internal and Preventive Medicine - Branch of Federal Research Center Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
2Novosibirsk State Medical University of Minzdrav of Russia, 630091, Novosibirsk, Krasny av., 52
3Rzhanov Institute of Semiconductor Physics of SB RAS, 630090, Novosibirsk, Akademik Lavrentiev av., 13
Keywords: система гемостаза, липидный профиль, Север, адаптация, механизмы, hemostasis system, lipid profile, North, adaptation, mechanisms
Abstract
The reviews analyzed the research data of recent decades, as a result of which the features of the hemostatic system and lipid profile in the North were studied, which allows us to look at development under conditions of successful adaptation to adverse conditions, as well as from the standpoint of inadequate reactivity of the system leading to the development of pathology. The results of meta-analyzes according to the association of the “Eskimo diet” with a hemostasis system, which analyzes the mechanisms of the antiplatelet effect of the omega-3 polyunsaturated fatty acids, are described in detail, a new physiological phenomenon of adaptation in the North is described - the reaction of the transformation of the inflammatory response, illuminated by new groups of physiological mediators (resolvines, maresins, etc.). Peculiarities of polymorphism of hemostasis factor genes that provide adaptation to the conditions of the North are noted. Affect the hemostatic system, adaptation mechanisms of the newcomer population.
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