Synthesis and Biological Study of Dialkyl(4-hydroxybut-2-ynyl)(3-phenyl-2,3-dichloroallyl)ammonium Chlorides,Their Intramolecular Cyclization and Recyclization of Obtained Products
A. R. GEVORGYAN
Institute of Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia
National Polytechnic University of Armenia, Yerevan, Armenia
E-mail: hasmikgevorgyan973@gmail.com
Keywords: intramolecular cyclization-dehydrochlorination, dialkyl(4-hydroxybut-2-ynyl)(3-phenyl-2,3-dichloroallyl)ammonium chlorides, intramolecular recyclization, dihydronaphto[1,2-с]furan derivatives, biological activity, antioxidant, anticoagulant
Pages: 126-130
Abstract
Potentially bioactive dialkyl(4-hydroxybut-2-ynyl)(3-phenyl-2,3-dichloroallyl)ammonium chlorides were synthesized. By base-catalyzed intramolecular cyclization of these salts and subsequent intramolecular recyclization of cyclic products 4-dialkylaminomethyl-5-chloro-1,3-dihydronaphto[1,2-c]furans were obtained. According to biological studies, dimethyl(4-hydroxybut-2-ynyl)(3-phenyl-2,3-dichloroallyl)ammonium chloride has anticoagulant and strongly pronounced antioxidant properties.
DOI: 10.15372/CSD2019119
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