Synthesis and Biological Activity of New N–aminoglycosides with Pyrazole Fragment
O. A. NURKENOV1, I. V. KULAKOV2 and R. A. ERMUKHANBETOVA3
a:2:{s:4:"TEXT";s:346:"1Institute of Organic Synthesis and Coal Chemistry of Kazakhstan, Ul. Alikhanova 1, Karaganda 100000 (Kazakhstan)
2Dostoevsky Omsk State University, Pr. Mira 55-a, Omsk 644077 (Russia)
E-mail: kulakov@chemomsu.ru
3Peoples’ Friendship University of Kazakhstan, Ul. Tole Bi 32, Shymkent 160000 (Kazakhstan)";s:4:"TYPE";s:4:"html";}
Keywords: N-aminoglycosides, glycosylation, monosaccharides
Pages: 151–154
Abstract
New aminoglycosides obtained by the interaction of (1,3,5-trimethyl-1-H-pyrazol-4-yl)methanamine with D-glucose and D-galactose have been characterized. The structure of the class of monosaccharide derivatives studied and their probable stereochemical (anomeric) composition have been established using modern physicochemical research methods (1HNMR and IR spectroscopy). A high growth promoting activity of N-aminoglycoside synthesized has been shown on the example of root formation of common bean.
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