Synthesis of Fluorinated Benzothiazoles, Study of Their Lithiation Sites and Subsequent Interaction with Dimethylformamide
V. E. ROMANOV1,2, E. V. PANTELEEVA1,2
1Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2Novosibirsk State University, Novosibirsk, Russia
Keywords: fluorinated benzothiazoles, lithium derivatives of benzothiazoles, formylation, methylation
Pages: 673–680
Abstract
The interaction of 4,6-difluoro-, 4-fluoro-, and 2-bromo-4,6-difluorobenzothiazole with BuLi or LiN[(CH3)3Si]2 in tetrahydrofurane, followed by the treatment with dimethylformamide and MeI, revealed the main metalation sites in these model mono- and difluorinated benzothiazoles. The reactivity of the resulting Li-derivatives with respect to formylation and methylation was also characterized.
DOI: 10.15372/CSD2023516
EDN: JKDIYX
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