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The journal "Ateroskleroz"

2016 year, number 3

SYSTEM OF HEMOSTASIS AND ATHEROGENESIS

A.A. Gromov1, M.V. Kruchinina1, Y.A.S. Schwartz1, V.N. Kruchinin2, S.V. Ryhlitsky2
1FSBSE «Scientific Research institute of therapy and preventive medicine», Novosibirsk
2Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Keywords: атеросклероз, гемостаз, тромбоциты, атеросклеротическая бляшка, система коагуляции, atherosclerosis, hemostasis, platelets, atherosclerotic plaque, coagulation system

Abstract

Atherosclerosis concept defines the key role of inflammation in the occurrence and progression of atherosclerosis. Hemostatic system is an integral part of the inflammatory response. At all stages of atherogenesis, starting from the early stages, there is part of hemostasis factors. In recent years researchers attract most interest to the questions of intercellular interaction between platelets and leukocytes. Combined evaluation of leukocyte-platelet responses reflect the clinical and laboratory picture of atherothrombotic events in unstable angina and myocardial infarction. Monocyte-platelet interaction plays a significant role in the development of heart failure, blood platelets are capable of inducing apoptosis. The individual testing the risk of hemorrhagic complications increase the efficiency of drug prevention and therapy of antithrombotic drugs. Changing the pattern of atherosclerosis observed in recent years, also requires the introduction of new approaches in the prevention of atherosclerosis, enhancing the protection of the endothelium. This review focuses on the research, covering the role of hemostasis in the pathogenesis of atherosclerosis.