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The journal "Ateroskleroz"

2016 year, number 3

1.
THE ROLE OF IL1Β CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASE

O.L. Barbarash, J.V. Bairakova, A.V. Ponasenko, M.V. Khutornaya, A.A. Kuzmina, Y.V. Kazachek, L.S. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Keywords: инфаркт миокарда, мультифокальный атеросклероз, интерлейкин , мультифокальный атеросклероз, интерлейкин - IL1β полиморфные сайты гена IL1β rs1143634, rs16944, myocardial infarction, multivessel coronary artery disease, interleukin - IL1β gene polymorphic sites IL1β rs1143634

Abstract >>
Objective: To evaluate the contribution of IL1β gene polymorphisms rs1143634 and rs16944 in the development of myocardial infarction (MI) and multivessel coronary artery disease in patients with CAD. Material and Methods: 303 patients with stable coronary artery disease were included in the study. Serum IL1β levels were measured with commercial kits (Bender MedSystems, Austria). TaqMan genotyping assays were performed in 96-well plate. Results: Women, who were homozygous carriers of the IL-1β rs1143634 G major allele, had a 4-fold decreased risk of developing multivessel coronary artery disease (p = 0.046) as well as a 2-fold decreased risk of myocardial infarction (p = 0.0198). The variable site of the IL1β rs1143634 was significantly (p = 0.0025) associated with a reduced risk of MI according to the dominant inheritance pattern (OR = 0.48, 95% CI = 0.29- 0.77), and rs16944 - with a five-fold increased risk (p = 0.0022) according to the co-dominant model (OR = 5.12, 95% CI = 1.82-14.42). The risk of myocardial infarction in men, who were homozygous carriers of the IL1β rs16944 T minor allele, was six times higher than that in women (p = 0.0093). The AC haplotype (rs1143634- rs16944) was associated with a 2-fold reduced risk of myocardial infarction and PICS (OR = 0.49, 95% CI = 0.29-0.81, p <0.0059), with the most pronounced effects in the age of 65 years (p = 0.0031). However, the GT haplotype rs1143634-rs16944 in younger patients (<65 years) was associated with the development of myocardial infarction (p = 0.0074). Conclusion: Genetic markers should be taken into consideration as an independent predictors of myocardial infarction and multivessel coronary artery disease.



2.
ASSOCIATION OF THE EXPRESSION OF CORONARY ATHEROSCLEROSIS WITH PSYCHOSOCIAL FACTORS IN PATIENTS WITH ACUTE CORONARY SYNDROME, LIVING IN THE NORTH CONDITIONS

K.G. Cojokhar1, I.A. Urvantseva1, K.Y. Nikolaev2
1SE KMAD - Yugra «Regional cardiologic dispensary "Center of diagnostics and cardiovascular surgery"», Surgut
2FSBSE «Scientific Research institute of therapy and preventive medicine», Novosibirsk
Keywords: острый коронарый синдром, психосоциальные факторы, тяжесть поражения коронарного русла по шкале SYNTAX, acute coronary syndrome, psychosocial factors, the severity of coronary lesions by SYNTAX score

Abstract >>
The aim of this study was to investigate the connection between coronary atherosclerosis severity, measured on a scale of the SYNTAX with psychosocial factors in patients with acute coronary syndrome who live in the North. The study involved 269 consecutive patients (n = 203, 21.2% female, n = 66, 78.8% - men) with acute coronary syndrome with the average age of 56,0 ± 6,1 years (45-64 years). It revealed a high level of alcohol consumption on the AUDIT scale in patients with severe coronary disease compared with mild and moderate (p = 0.03). Direct correlation among severity of coronary lesions, a total cholesterol (r = 0,15, p <0,05) and low density lipoprotein cholesterol (r = 0,15, p <0,05) in patients with severe coronary disease were found out. With the help of binary logistic regression it was stated that the low level of instrumentally support increases in 2,16 times the risk of presence of acute coronary syndrome ona scale of the SYNTAX (p = 0,02), however, the age (p = 0.06) and male gender (p = 0 94) did not significantly influence the dependent variable above.



3.
ATRIAL FIBRILLATION: PREVALENCE AND CROSS-SECTIONAL DETERMINANTS IN NOVOSIBIRSK POPULATION (HAPIEE COHORT, 9255 PARTICIPANTS)

M. Shapkina1, A. Ryabikov1, E. Voronina1, E. Mazdorova1, L. Sherbakova1, M. Bobak2, S. Malyutina1
1FSBSE «Scientific Research institute of therapy and preventive medicine», Novosibirsk, Russia
2University of London, London, United Kingdom
Keywords: фибрилляция предсердий, распространенность, детерминанты, артериальная гипертензия, atrial fibrillation, the prevalence, determinants, hypertension, cross-sectional study

Abstract >>
Objectives: to investigate the prevalence and determinants of AF in cross-sectional study in a population sample 45-69 age (Novosibirsk). Materials and methods: a random population sample of men and women 45-69 years old (y. o.) (n=9360) was examined in Novosibirsk (project HAPIEE). We used standard epidemiological methods. As optional study ECG was registered participants and estimated by Minnesota code (n=9255). They were included for current analysis (grant RSF 14-45-0030). Results: in studied population sample the prevalence of AF was 1.6% (1.1% in women and 2.1% in men). The frequency of AF increased with age: from 0.3% in age group of 45-49 y. o. in both sexes to 4.0% in men and 2.8% in women in the oldest age group (65-69 y. o.), p<0.001. In unadjusted analysis, in men AF was associated with elder age, heart rate (HR) (р<0,001), diastolic blood pressure (р=0,003), body mass index (BMI) (р<0,001), presence of cardiovascular disease (CVD), hypertension (HT) (р<0,001) and diabetes mellitus (DM) (р=0,002). When we have compared laboratory parameters, the patients with AF had lower level of total cholesterol (TC) (р=0,001), low-density lipoprotein cholesterol (LDL-C) (р=0,005) and higher level of gamma-glutamyltranspeptidase (GGT) (p <0.001). The significant difference of alcohol consumption measures in relation to AF we did not identified in population sample. In women were similar results in the studied risk factors and cardiometabolic diseases. In multivariate regression, AF in men was positively associated with age, HR, BMI (p<0.001) and negatively related to level of triglycerides (p=0.019) and LDL-C level (p=0.001). Women had a positive association of AF with age, HR, BMI (p<0.001), GGT (p=0.002) and negative - to LDL-C level (p<0.001). Conclusions: in a population sample 45-69 y. o. of Novosibirsk the prevalence of AF was 1.6%, which is close to indicators in other populations. Determinants of AF were CVD, HT, DM, HR, BMI, increasing age (for both sexes) and GGT level in women. We did not find the direct relationship between AF and the atherogenic lipid profile; these results are likely to be associated with the modulating contribution of cardiometabolic factors.



4.
EFFICIENCY DETECTION OF CARDIOVASCULAR DISEASES AND RISK FACTORS IN THE DEVELOPMENT OF THEIR CLINICAL EXAMINATION OF CERTAIN GROUPS OF ADULTS IN THE SIBERIAN FEDERAL DISTRICT

O.J. Kutumova1,2, M.L. Fomicheva3,4
1Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science, Krasnoyarsk
2Federal State Scientific Institution "Federal Research Center" Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences ", Krasnoyarsk
3State health public institutions novosibirsk region "Regional medical center for prevention", Novosibirsk
4FSBSE «Scientific Research institute of therapy and preventive medicine», Novosibirsk
Keywords: Сибирский федеральный округ, сердечно-сосудистые заболевания, диспансеризация, Siberian Federal District, cardiovascular disease, clinical examination

Abstract >>
Clinical examination in our country has a long history. National health care has significant experience in the clinical examination of the population and its separate contingents. Cardiovascular disease is one of the priorities for preventive measures among the population. During the event, using the experience, formed the modern concept of the clinical examination of the adult population.



5.
SYSTEM OF HEMOSTASIS AND ATHEROGENESIS

A.A. Gromov1, M.V. Kruchinina1, Y.A.S. Schwartz1, V.N. Kruchinin2, S.V. Ryhlitsky2
1FSBSE «Scientific Research institute of therapy and preventive medicine», Novosibirsk
2Institute of Semiconductor Physics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk
Keywords: атеросклероз, гемостаз, тромбоциты, атеросклеротическая бляшка, система коагуляции, atherosclerosis, hemostasis, platelets, atherosclerotic plaque, coagulation system

Abstract >>
Atherosclerosis concept defines the key role of inflammation in the occurrence and progression of atherosclerosis. Hemostatic system is an integral part of the inflammatory response. At all stages of atherogenesis, starting from the early stages, there is part of hemostasis factors. In recent years researchers attract most interest to the questions of intercellular interaction between platelets and leukocytes. Combined evaluation of leukocyte-platelet responses reflect the clinical and laboratory picture of atherothrombotic events in unstable angina and myocardial infarction. Monocyte-platelet interaction plays a significant role in the development of heart failure, blood platelets are capable of inducing apoptosis. The individual testing the risk of hemorrhagic complications increase the efficiency of drug prevention and therapy of antithrombotic drugs. Changing the pattern of atherosclerosis observed in recent years, also requires the introduction of new approaches in the prevention of atherosclerosis, enhancing the protection of the endothelium. This review focuses on the research, covering the role of hemostasis in the pathogenesis of atherosclerosis.



6.
HYPOLIPIDEMIC MEDICATIONS: CURRENT USE AND FUTURE PERSPECTIVES. PART 3. STATIN’S USING IN DIFFERENT PATIENT’S CATEGORY

A. E. Bagriy, A. I. Dyadyk, M. V. Khomenko, I.N. Tsiba, V. A. Efremenko, E. V. Schukina, O. A. Prikolota
Donetsk National Medical University name M. Gorky, Donetsk
Keywords: статины, атеросклероз-ассоциированные заболевания, семейные гиперхолестеринемии, statins, atherosclerosis-associated disease, familial hypercholesterolaemia

Abstract >>
This article is devoted to discussion about statin’s using in patients with atherosclerosis-associated disease, arterial hypertension, diabetes mellitus, chronic kidney disease, familial hypercholesterolaemia, rheumatoid arthritis, systemic lupus erythematosus, nonalcoholic fatty liver disease and gallstone disease.



7.
PRESENT VIEW ON THE PROBLEMS OF ATHEROSCLEROSIS: REVIEW OF MATERIALS OF THE 84RD CONGRESS OF THE EUROPEAN ATHEROSCLEROSIS SOCIETY

D.E. Ivanoshchuk, E.V. Shakhtshneider
FSBSE «Scientific Research institute of therapy and preventive medicine», Novosibirsk
Keywords: атеросклероз, метаболизм липидов, семейная гиперхолестеинемия, ожирение, сердечно-сосудистые заболевания, atherosclerosis, lipid metabolism, familial hypercholesterolaemia, obesity, cardiovascular diseases

Abstract >>
The 84rd European Atherosclerosis Society (EAS) Congress was held in Innsbruck, Austria, 28 May-1 June 2016. The Congress program discussed the latest scientific data and clinical studies. Angiogenesis and vascular metabolism, familial hypercholesterolemia, obesity, lifestyle and cardiovascular diseases, personalized medicine were the main topics of the discussion. The review was prepared based on the EAS Congress 2016 materials and the websitehttp://www.eas2016.kenes.com/.