Synthesis and Safety Evaluation of Gold Nanoparticles in the in Vivo Experiment
TATYANA G. TOLSTIKOVA1, MIKHAIL V. KHVOSTOV1, NATALYA A. ZHUKOVA1, NADEZHDA V. SHIKINA2, ZINFER R. ISMAGILOV2,3
1Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
2Boreskov Institute of Catalysis, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
3Institute of Coal Chemistry and Material Science, Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Kemerovo, Russia
Keywords: gold nanoparticles, toxicity, peripheral blood, behaviour, microscopic examination, outbred mouse, C57BL/6j mice
Abstract
In continuation of works on toxicology of nanocarbon materials, investigations of safety of colloidal gold nanoparticles in the 10 to 40 nm size range in two lines of mice (outbred and line C57BL/6j) were performed. It was shown that in 24 h and 30 days after a single parenteral injection of colloidal gold nanoparticles in mice, the toxic action on indicators of peripheral blood, behaviour of animals, as well as internal organs was not revealed.
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