Pharmacological Properties of the Complexes of Plant Carbohydrate-Containing Metabolites with the Agents Affecting the Cardiovascular System
M. V. Khvostov, A. O. Bryzgalov, T. G. Tolstikova
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
mihail.hvostov@gmail.com
Keywords: complexes, plant metabolites, antihypertensive and antiarrythmic properties
Pages: 453-459
Abstract
Antihypertensive and antiarrythmic properties of the complexes of glycyrrhizic acid (glycoside of licorice roots), glycosides of Stevia rebaudiana Bertoni (stevioside, enzymatically treated stevioside SWETA and rebaudioside), arabinogalactan (polysaccharide of Siberian Larch) with propranolol, amiodarone and nifedipine were investigated. It was established that all the studied complexes of nifedipine except the complex of nifedipine with rebaudioside at the molecular ratio of 1 : 4 are promising for further pharmacological examination. The complex of propranolol with glycyrrhizic acid at the molecular ratio of 1 : 4 in the dose of 0.0025 mg/kg is also distinguished; it demonstrated good antiarrythmic activity. In the case of complexes with amiodarone, it may be concluded that complexing of this pharmacon with carbohydrate-containing plant metabolites used in our experiments does not lead to the desirable decrease in efficient dose but, quite contrary, worsens its antiarrythmic effect.
|
