Computer Analysis of Biological Activity Spectrum for Novel Betulonic Acid Derivatives
D. S. Baev, I. V. Sorokina, T. G. Tolstikova
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
sorokina@nioch.nsc.ru
Keywords: derivatives of betulonic acid, structure-to-properties relations, PASS program
Pages: 389-395
Abstract
Analysis of the structure-to-properties relations for the new derivatives of betulonic acid was carried out with the help of PASS program. Agents with potentially high antitumor, hepatoprotective and anti-inflammatory activity were revealed among these compounds. Analysis of the possible mechanisms of the action of novel betulonic acid derivatives was carried out.
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