Synthesis and Investigation of the Pharmacological Activity of Oreoselone Nitrogen-Containing Derivatives
A. V. Lipeeva, E. E. Shults, E. A. Morozova, T. G. Tolstikova, G. A. Tolstikov
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
morozova@nioch.nsc.ru
Keywords: furocoumarins, bromoreoselone, 2-(1, 3-dibromopropane-2-ylidene)-2Н-furo-[3, 2-g][1]benzopyran-3, 7-dione, motion activity, chloral hydrate sleep
Pages: 381-388
Abstract
The bromination of peucedanine using different reagents resulted in the formation of 2-bromoreoselone. Via the reaction with the derivatives of piperidine and piperazine we synthesized 2-piperazino and 2-piperidino derivatives of oreoselone. Conditions were determined for the formation of 2-(1,3-dibromopropane-2-ylidene)-2Н-furo-[3,2-g][1]-benzopyran-3,7-dione. The interaction of the latter with tyramine resulted in obtaining bis(diaminophenethyl) derivative of furocoumarin. The amination of the mentioned dibromide with the help of spermine resulted in the formation of a macrocyclic compound containing both furocoumarin and polyamine fragments. The effect of novel oreoselone derivatives on the central nervous system was investigated.
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