CRYSTAL STRUCTURE AND ANTITUMOR ACTIVITIES OF THE DICHLORIDE 2,6-bis(1-PHENYLBENZIMIDAZOL-2-YL)PYRIDINE COPPER(II) COMPLEX
Q.-W. Huang1, S.-G. Liu1, G.-B. Li1, S.-X. Wang2, W.-Y. Su1, D.-M. Liang1, S.-Q. Mao1
1Lingnan Normal University, Zhanjiang, P.R. China
lsgui@sohu.com
2Shenzhen University, Shenzhen, P.R. China
Ключевые слова: benzimidazole, copper complex, crystal structure, antitumor activities
Страницы: 487-491
Подраздел: КРАТКИЕ СООБЩЕНИЯ
Аннотация
A new complex Cu(bpbp)Cl2×DMF×H2O is synthesized by treatment of CuCl2 with 2,6-bis(1-phenylbenzimidazol-2-yl)pyidine in DMF. Its structure is characterized by elemental, IR, UV, and single crystal X-ray structure analyses. For the complex: crystal system, triclinic, space group P ī, a = 1.0537(1) nm, b = 1.1735(1) nm, c = 1.3749(2) nm, α = 112.275(2)°, β = 91.531(2)°, γ = 97.700(2)°, V = 1.553(4) nm3, Z = 2. In a distorted trigonal bipyramidal geometry the Cu(II) ion is coordinated by three nitrogen atoms from 2,6-bis(1-phenylbenzimidazol-2-yl)pyridine and two chloride ions. The antiproliferative activities of the complex are screened by MTT assay against HepG2, Huh7, Eca109, and Eca9706 cancer cells. The complex exhibits specific inhibition on Eca9706 cancer cells with the IC50 value of 28 mM after 48 h treatment. CCDC: 968927.
DOI: 10.15372/JSC20150308 |
