Издательство СО РАН

Издательство СО РАН

Адрес Издательства СО РАН: Россия, 630090, а/я 187
Новосибирск, Морской пр., 2

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Поиск по журналу

Журнал структурной химии

2008 год, номер 3

SYNTHESIS AND CONFORMATIONAL ANALYSIS OF SOME CYANOMETHYLENE DERIVATIVES OF PIPERIDINES

A. Manimekalai, J. Anusuya, J. Jayabharathi
Ключевые слова: molecular conformations, saturated heterocycles, six-membered heterocycles, computations, NMR spectra, mass spectra, A1, 3 strain
Страницы: 465-475

Аннотация

Five 4-dicyanomethylene derivatives 6-10, N-cyanoacetyl-<i>cis</i>-2,6-diphenylpiperidin-4-one 11 and 4-cyano(ethoxycarbonyl)-methylene-<i>cis</i>-2,6-bis(<i>o</i>-chlorophenyl)piperidine 12 were synthesised by condensing the appropriate piperidin-4-ones 13-17 with malononitrile/ethylcyanoacetate and their <sup>1</sup>H and <sup>13</sup>C NMR spectra were recorded. The <sup>1</sup>H-<sup>1</sup>H COSY spectrum for 6 and NOESY spectra for 8, 10 and 11 were also recorded. Based on coupling constants and the results obtained from NOESY spectra boat conformation for 10 and epimerised chair conformations for 8 and 9 have been proposed. Other derivatives adopt normal chair conformations. Theoretical calculations and the <sup>1</sup>H and <sup>13</sup>C chemical shifts also support the above conformations. Mass spectra were also recorded for 6-12.