Главная – Журналы – Химия в интересах устойчивого развития 2023 номер 3

This is a study on antiviral activity of various extracts from the plant Monarda fistulosa L. cultivated in the forest-steppe zone of Western Siberia during the vegetation period. The activity of aqueous and aqueous-ethanolic extracts of M. fistulosa during the whole vegetation period and two polyphenolic fractions from this plant at the flowering stage was investigated against human influenza virus A/Aichi/2/68 (H3N2) and avian influenza virus A/chicken/Kurgan/05/2005 (H5N1). The anti-influenza activity was compared among the extracts and the polyphenolic fractions from M. fistulosa at the flowering stage. It was shown that antiviral activity against each subtype of the influenza A virus differed throughout the entire vegetation period, depending on the developmental stage of M. fistulosa and the type of extraction. Influenza virus A/Aichi/2/68 (H3N2) infectivity was most strongly inhibited by aqueous-ethanolic extracts from M. fistulosa raw material collected at the growth stage and by the aqueous extract from the fruiting initiation stage. Inhibition of the infectivity of influenza virus A/chicken/Kurgan/05/2005 (H5N1) was achieved by one or another M. fistulosa extract almost throughout the whole vegetation period. It is found that Polyphenolic Fractions 1 and 2 are more active against influenza virus A/Aichi/2/68 (H3N2), but aqueous and aqueous-ethanolic extracts are more active against influenza virus A/chicken/Kurgan/05/2005 (H5N1). On the condition of further in-depth studies, our experimental data suggest that M. fistulosa plant components can be recommended as medicinal (antiviral) substances against influenza viruses A/Aichi/2/68 (H3N2) and A/chicken/Kurgan/05/2005 (H5N1).