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The journal "Ateroskleroz"

2021 year, number 1


A.A. Ivanova1, S. K. Malyutina1, V. P. Novoselov2, A Rodina. I.3, O. V.З. Khamovich3, V. N. Maximov1
1Federal Research Center Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2Novosibirsk State Medical University of Minzdrav of Russi, Novosibirsk, Russia
3Novosibirsk regional clinical bureau of forensic medical examination, Novosibirsk, Russia
Keywords: sudden cardiac death, single nucleotide polymorphism, genome- wide allelotyping


The aim of the research is to verify the association with sudden cardiac death (SCD) of single nucleotide polymorphisms rs10867772 and rs4700290, identified as new molecular genetic markers of SCD in the own genome-wide pooled allelotyping. Material and methods. Case-control study. The SCD group is formed using the criteria of the European Society of Cardiology from the DNA bank of suddenly deceased residents of the Oktyabrsky district of Novosibirsk (n = 437, average age - 53.1 ± 9.0 years, men - 73.5%, women - 26.5%) The control group (n = 405, average age 53.2 ± 9.2 years, men - 70.0%, women - 30.0%) is formed from the DNA bank of participants of MONICA and HAPIEE projects. DNA was isolated by phenol-chloroform extraction from myocardial tissue in the SCD group and venous blood in the control group. Genotyping was performed by the PCR-RFLP method. Results. No statistical significance was found in allele and genotype frequencies of rs10867772 and rs4700290 between groups, even in separating in sex and age (p> 0.05). Conclusion. Single nucleotide polymorphism rs10867772 and rs4700290 are not associated with SCD.