Risk factors in patients with non-alcoholic fatty liver disease associated with arterial hypertension, overweight and obesity
Yuri A. Nikolaev, Evgenia V. Sevostyanova, Vladimir Ya. Polyakov, Igor M. Mitrofanov, Alina A. Us
Federal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia
nicol@centercem.ru
Keywords: non-alcoholic fatty liver disease, arterial hypertension, overweight, obesity, risk factors
Abstract
Purpose of the study was to
investigate the features of the occurrence of risk factors in patients
with non-alcoholic fatty liver disease associated with arterial
hypertension, overweight and obesity. Material and methods. The object
of the study was the data of 14 393 case histories of patients with
arterial hypertension (AH), non-alcoholic fatty liver disease (NFLD),
overweight body (OB) and obesity, examined and treated at the clinic of
the Federal Research Center for Fundamental and Translational Medicine
(Novosibirsk). Results and discussion. Features of biochemical
parameters in patients with NFLD with AH, OB and obesity were studied in
comparison with patients with isolated diseases. It was shown that in
patients, in case of the presence of this comorbidity, the value of
transsystem polymorbidity is statistically significantly increased
compared with groups of patients with isolated diseases. It was
established that patients with concomitant diseases have higher,
statistically significant values of systolic and diastolic blood
pressure, body mass index. They have higher concentrations of total
cholesterol, triglycerides, high density lipoprotein cholesterol,
glucose, uric acid in the blood serum, higher atherogenic index. A study
of the frequency of occurrence of risk factors in the groups showed the
highest frequency values in patients with associated diseases: high
blood pressure, dyslipidemia, hypertriglyceridemia,
hypercholesterolemia, hypoalphacholesterolemia, hyperlipidemia,
increased atherogenic index, hyperglycemia, hyperuricemia, the higher
levels of C-reactive protein, which indicates that with associated
pathology, changes in carbohydrate, lipid and purine metabolism are more
pronounced. These changes are factors that aggravate the course of the
pathology and are risk factors for the development of diabetes mellitus,
atherosclerosis and associated conditions, which requires a
personalized approach to the treatment and prevention of this category
of patients. The results of this study can form the basis for the
development of new medical technology for assessing the severity of
condition in patients with non-alcoholic fatty liver disease combined
with arterial hypertension, overweight and obesity.
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