The role of hematological parameters as predictors of mortality in elderly patients in the hospital period
Lyudmila V. Borisova1,2, Svetlana A. Rukavishnikova3,4, Alexander S. Pushkin5,6,7, Timur A. Akhmedov3,4, Vladimir V. Yakovlev8
1Saint-Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, Russia
lucibor@yandex.ru
2City multidisciplinary hospital № 2
3City multidisciplinary hospital № 2, Saint-Petersburg, Russia
kdlb2@yandex.ru
4First Pavlov State Medical University of St. Petersburg of Minzdrav of Russia
timaxm@gmail.ru
5Saint-Petersburg
Institute of Bioregulation and Gerontology, Saint-Petersburg, Russia
pushkindoc@mail.ru
6City multidisciplinary
hospital № 2
7First Pavlov State Medical University of St. Petersburg of
Minzdrav of Russia
8Military medical Academy of S.M. Kirov, Saint-Petersburg, Russia
yakovlev-mma@yandex.ru
Keywords: acute coronary syndrome, hematological parameters, predictors, elderly and senile age
Abstract
The development of
algorithms for predicting adverse outcomes, including death in elderly
and senile patients, is an urgent issue. Potential predictors include
hematologic parameters. A clinical blood test is one of the most
affordable diagnostic methods in practical medicine, reflecting systemic
pathological processes in the human body based on a quantitative
assessment of the cellular composition and blood morphology. The aim of
this study was to evaluate hematological parameters as predictors of
in-hospital mortality in patients of the elderly and senile age with
acute coronary syndrome. Material and methods. The study included 277
patients with acute coronary syndrome. The study of hematological
parameters was carried out on a CELL-DYN Sapphire hematology analyzer
(Abbott Laboratories, USA). The values of neutrophil-lymphocytes ratio
and platelet-lymphocytes ratio were also evaluated as predictors of
in-hospital mortality. Results. High content of leukocytes (above 10.45 ×
109/l) during hospitalization in patients with ACS aged
60-74 years are associated with a higher risk of death at the hospital
stage. Among patients with ACS aged 75-89 years, the risk of death is
associated with the following changes in peripheral blood upon
admission: a decrease in the absolute number of eosinophils below 0.086 ×
109/l, an increase in the absolute number of basophils above 0.079 × 109/l and a decrease in platelet-lymphocytes ratio below 31.06.
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