Prevalence of gastroesophageal reflux disease, gastroduodenal erosions and ulcers and their association with the family predisposition to peptic ulcer disease in Siberian schoolchildren
Tamara V. Polivanova1, Eduard V. Kasparov2, Vitaliy A. Vshivkov2, Olga V. Peretyatko2, Timur N. Akhmetshin2
1Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky of Minzdrav of Russia, Krasnoyarsk, Russia
tamara-polivanova@yandex.ru
2Scientific Research
Institute for Medical Problems of the North of Federal Research Centre
В«Krasnoyarsk Scientific Centre» Siberian Division of Russian Academy of
Sciences, Krasnoyarsk, Russia
impn@impn.ru
Keywords: распространенность, дети, гастроэзофагеальная рефлюксная болезнь, эрозивно-язвенные поражения, наследственная предрасположенность, язвенная болезнь, Сибирь, prevalence, children, GERD, erosive and ulcerative lesions, hereditary predisposition, peptic ulcer disease, Siberia
Abstract
The aim is to study the
prevalence of gastroesophageal reflux disease (GERD), gastroduodenal
erosions and ulcers and their association with a family predisposition
for ulcer disease in Siberian schoolchildren. Material and methods. We
have examined schoolchildren aged 7-17 years in three regions of Siberia
(Republic of Tyva, Evenkia and Buryatia) in localities identical to
their socio-economic level. Data collected using a cross-sectional
method using standardized questionnaires on the presence of
gastroenterological complaints and information about ulcer disease of
relatives in the 1st and 2nd generations in 1535 schoolchildren in Tuva,
790 in Buryatia and 1369 in Evenkia. Diagnosis of GERD was based on the
presence of complaints of heartburn, in accordance with international
consensus in the pediatric population. We performed gastroscopy randomly
method in each region at schoolchildren with gastrointestinal
complaints (283 children in Tyva, 110 in Buryatia, 205 in Evenkia).
Results. There was an increase in the GERD frequency among Siberian
children with anamnesis data on the presence of peptic ulcer in
relatives (9.9 and 5.9 %, respectively, p = 0.0025). The most
unfavorable situation has been observed in the population of
schoolchildren of the Republic of Tuva (10.6 % with a burdened history
and 9.3 % without it, p = 0.5389). We have not revealed the significant
increase of gastroduodenal erosions and ulcers in children with a poor
family history of peptic ulcer disease (12.6 and 10.4 %, respectively, p
= 0.5263), including Tuva schoolchildren where they were more often
detected. The GERD association with erosive ulcerative process in the
mucous membrane of the stomach and duodenum was ambiguous and had
population (regional) features in schoolchildren with a burdened family
history of peptic ulcer disease. Conclusion. Siberian schoolchildren
with a family predisposition to peptic ulcer disease have certain
regional features in the association of gastroduodenal erosions and
ulcers with GERD.
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