Dynamics of postsurgical wound local changes and healing rate during the use of alpha-glutamyl-tryptophan in combination therapy of patients with skin and soft-tissue infections
Alina R. Kasimova1,2, Irina S. Petlenko3, Svetlana A. Bozhkova3
1Vreden Russian Research
Institute of Traumatology and Orthopedics of Minzdrav of Russia
kasi-alina@yandex.ru
2Academician I.P. Pavlov First Sankt-Petersburg State Medical University
of Minzdrav of Russia
3Vreden Russian Research Institute of Traumatology and Orthopedics of Minzdrav of Russia
petlenko1995@yandex.ru
Keywords: инфекции кожи и мягких тканей, иммунотропная терапия, иммуномодулятор, альфа-глутамил-триптофан, заживление послеоперационных ран, skin and soft tissue infections, immunotropic therapy, immunomodulator, alpha-glutamyl-tryptophan, postoperative wound healing
Abstract
Skin and soft-tissue
infections (SSTI) take the lead in surgical disorders. Changes of local
and systemic immunoreactivity highlight the SSTI and hinder treatment
due to disease chronicity. The immunotropic therapy could be the useful
tool in SSTI treatment. The aim of the study was to assess the dynamics
of local changes and and duration of wound healing during the use of
alpha-glutamyl-tryptophan (AGT/Thymogen) in the combination therapy of
SSTI patients. Material and methods. A sample of 77 individuals aged
18-55 years with moderate SSTI of different localization and with signs
of infectious intoxication participated in the randomized, double-blind,
parallel group, placebo-controlled clinical trial. The patients were
divided into the main (39 people) and control (38 people) groups. The
combination therapy of the main group included 100 μg of AGT by
intramuscular injection daily during 7 days, whereas the control group
received placebo (0,9 % sodium chloride) along the same schedule.
Results and discussion. The combination therapy of SSTI patients with
AGT significantly decreased the local inflammation, i.e. pain intensity,
hyperemia, edema ( p = 0,022), infiltration within damage area ( p =
0,03). Besides, AGT treatment leads to statistically and clinically
significant reduction in the duration of septic wound healing by an
average of 2 days as compared to control group. Thus, statistically, and
clinically significant superiority of efficacy of
alpha-glutamyl-tryptophan in comparison with placebo in reducing the
time of healing of purulent wounds of patients with SSTI has been
established.
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