Estimation of acute toxicity of a drug based on the complex of lithium citrate, polymethylsiloxane, aluminum oxide
Maxim A. Korolev1, Lyubov N. Rachkovskaya1, Pavel G. Madonov1, Anna V. Shurlygina1, Edmund E. Rachkovsky1, Andrey Yu. Letyagin1, Vladimir I. Konenkov1, Alexey A. Churin2, Tatyana Yu. Dubskaya2, Tatyana V. Vetoshkina2, Lyubov A. Sandrikina2, Tatyana I. Fomina2, Elena P. Fedorova2
1Research Institute of
Clinical and Experimental Lymphology - a branch of the Federal Research
Center for Cytology and Genetics SB RAS, Novosibirsk, Russia
kormax@bk.ru
2Research Institute of Pharmacology and Regenerative Medicine of Tomsk National Research Medical Center, Tomsk, Russia
churin_aa@pharmso.ru
Keywords: лекарственные препараты лития, комплекс лития цитрата, полиметилсилоксана и оксида алюминия, острая токсичность, lithium drugs, complex of lithium citrate, polymethylsiloxane and aluminum oxide, acute toxicity
Abstract
Research Institute of
Clinical and Experimental Lymphology has developed an innovative drug
based on a complex of lithium citrate, polymethylsiloxane and aluminum
oxide (LOAP). Lithium-based drugs are effective in treating bipolar
disorders. However, the toxic effects of lithium cause a “narrow
therapeutic window”, which limits its clinical use. The creation of the
drug LOAP was aimed at creating a prolonged form with a slow release of
lithium to reduce toxic properties and use lithium citrate as an active
pharmacological agent. At the moment, the lithium complex has no
analogues. The purpose of the study was to study the parameters of acute
toxicity of the LOAP. Material and methods. When studying acute
toxicity, drugs were administered once intragastrically to mice and rats
at doses of 12000, 10000, and 5000 mg/kg. Results. A single
administration of drugs intragastrically through a probe in the maximum
possible doses to mice and rats did not cause the death of animals and
did not cause a locally irritating effect on the gastric mucosa. LOAP
can be assigned to hazard class 4 (GOST 12.1.007-76).
|
