Vitamin D (steroid hormone) and the nervous system diseases (literature review)
Denis A. Novotnyy1, Natalia G. Zhukova2, Larisa P. Shperling1, Valentina A. Stolyarova2, Irina A. Zhukova2, Anna E. Agasheva2, Stanislav V. Shtaimets2, Oksana A. Druzhinina1
1Regional Center of Extrapyramidal Diseases with the Cabinet of Botulinum Therapy, Novosibirsk, Russia
hellpost@yandex.ru
2Siberian State Medical University of Minzdrav of Russia, Tomsk, Russia
znatali@yandex.ru
Keywords: витамин D, заболевания головного мозга, хронические заболевания нервной системы, болезнь Паркинсона, болезнь Альцгеймера, vitamin D, brain diseases, chronic nervous system diseases, Parkinson’s disease, Alzheimer’s disease
Abstract
The present review aims to
summarize the activities of vitamin D effects on the nervous system and
to clarify a vitamin D role in brain diseases, in the pathogenesis or as
a serum biomarker for the disease development and severity. Objective:
correlation between chronic nervous system diseases and vitamin D level.
Methods: a literature research in PubMed and in Russian electronic
resources by keywords: vitamin D, brain diseases, chronic nervous system
diseases. Results. Vitamin D as a neurosteroid hormone stimulates
cerebral activity in both adult and embryonic brain regulates the
activity of neural circuits which are responsible for locomotor,
reward-dependent and emotional behavior. Patients with autism spectrum
disorders, schizophrenia, Alzheimer disease, multiple sclerosis,
Parkinson disease and sleep disorders have been shown to have low level
of vitamin D. Discussion. Data are controversial, a further study of
vitamin D hypovitaminosis significance is essential for the nervous
system chronic diseases manifestation and evaluation of the vitamin D
dietary supplement efficiency in patients with the nervous system
pathology.
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