Genetics of "atopic march" syntropy
Elena Yu. Bragina1, Maxim B. Freidin1, Valery P. Puzyrev1
Research Institute of Medical Genetics of Tomsk NRMC of RAS, Tomsk, Russia
elena.bragina72@gmail.com
Keywords: синтропия, коморбидность, "атопический марш", гены синтропий (коморбидности), syntropy, comorbidity, "atopic march", syntropic genes (genes of comorbidity)
Abstract
The study of the phenomenon
of a combination of several diseases at the same time in an individual,
actualized in the second half of the 19th century, is being actively
analyzed 150 years later using genetic approaches. We present an
overview of the results of such studies in relation to allergic
diseases, in particular, a special variant, the so-called «atopic
march», the sequential development of eczema, allergic rhinitis and
asthma («atopic march» syntropy). The data of genetic and
epidemiological studies were summarized, the analysis of genome-wide
associative studies was carried out, and the role of mutations in the
filaggrin gene ( FLG ) in the development of the «atopic march» syntropy
was considered.
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