GENES OF APOA5 AND APOH APOLIPROTEINS AS REGULATORS OF LIPOPROTEIN METABOLISM
N.S. Shirokova1, S.V. Mikhailova2, D.E. Ivanoshchuk2,3, E.V. Shachtshneider2,3
1Novosibirsk State University, 630090, Novosibirsk, Pirogov str., 1
2Federal Research Center Institute of Cytology and Genetics of SB RAS, 630090, Novosibirsk, Academician Lavrentiev av., 10
3Research Institute of Internal and Preventive Medicine, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: аполипопротеины, атеросклероз, триглицериды, ген APOA5, ген APOH, apolipoproteins, atherosclerosis, triglycerides, APOA5 gene, APOH gene
Abstract
Atherosclerosis is main cause of cardiovascular disease leading to disability and death worldwide. Many factors can affect atherogenesis, including hypertension, smoking, diabetes mellitus and inflammatory processes. It is known that disorders of cholesterol and triglycerides It is known, that violation in cholesterol and triglyceride metabolism caused by substitutions in the structure of apolipoproteins are associated with a predisposition to hyperlipidemia and atherosclerosis. Despite the increased interest in the atherogenesis mechanisms, many participants in this process are not fully understood. In this review, we examined the structure and functions of two proteins - apolipoprotein A5 and apolipoprotein H in connection with their association with impaired lipid metabolism.
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