Home – Home – Jornals – The journal "Ateroskleroz" 2020 number 2

Aim of the study was to identify associations of polyphenolic compounds consumption in general and their individual classes with excess body weight in the population of Novosibirsk. Material and methods. In 2003-2005, in the frames of the HAPIEE international project «Determinants of cardiovascular diseases in Eastern Europe: a multicenter cohort study» the population sample aged 45-69 (9360 people, 4266 men and 5094 women, average age - 57.6 years) was examined in Novosibirsk. The calculation of body mass index (BMI) was carried out according to the formula: BMI (kg / m²) = weight (kg) / height² (m²). The BMI classification of obesity was used (WHO, 1997). For the analysis of nutrition, we used a semi-quantitative frequency questionnaire - Food Frequency Questionnaire (FFQ) and the European database Phenol-Explorer 3.6. Results. The chance of developing overweight in women decreases by 24% with high polyphenols consumption in general: odds ratio (OR) 1.24 (confidence interval (CI) 1.01-1.53), p = 0.048. For a high consumption of phenolic acids in the whole population, the probability decreases by 26 %: OR 1.26 (CI 1.11-1.44), p < 0.001; in women - by 57 %: OR 1.57 (CI 1.27-1.94), p < 0.001. In a population, the probability of developing overweight with a high consumption of stilbenes decreases by 21 %: OS 1.21 (CI 1.06-1.4), p = 0.004, in women - by 37 %: OS 1.37 (CI 1,11-1.7), p = 0.003; for the class of other polyphenols, the chance decreased in the population by 30 %: OR 1.3 (CI 1.13-1.46), p = 0.001, in women by 50 %: OR 1.5 (CI 1.22-1.84 ), p < 0.001. Conclusions. High levels of polyphenols consumption in general, as well as phenolic acids, stilbenes, and the class of other polyphenols reduced the chance of overweight developing.