Technique of aerosol generation of antibacterial medicine cefazolin
A.A. Bazhina1,2, S.V. Valiulin1,2, A.M. Baklanov1, S.N. Dubtsov1, S.V. An'kov1,3, M.E. Plokhotnichenko1, T.G. Tolstikova1,3, A.A. Onischuk1,2
1V.V. Voevodsky Institute of Chemical Kinetics and Combustion of the Siberian Branch of the RAS, Novosibirsk, Russia
2Novosibirsk State Pedagogical University, Novosibirsk, Russia
3N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Novosibirsk, Russia
Keywords: наночастицы, аэрозоль, ингаляционное введение, цефазолин, антибиотик, nanoparticles, aerosol, lung drug administration, cefazolin, antibiotic
Abstract
Technique for generation of cefazolin aerosol particles with the size from 80 to 1400 nm is described. Experiments with aerosol drug administration on laboratory animals (mice) showed the efficiency of this cefazolin delivery technique to be close to the efficiency of intravenous injection.
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