ROLE OF ENDOTHELIAL DYSFUNCTION IN THE FORMATION OF COGNITIVE IMPAIRMENT
M.A. Khoreva1, E.N. Vorobyeva1,2, G.I. Shumacher1,2, R.I. Vorobyev3, I.A. Batanina2
1Altai State Medical University of the Ministry of Health of the Russian Federation, 656038, Barnaul, Lenin av., 40
2CHUZ "Clinical Hospital "RZD-Medicine" of Barnaul", 656038, Barnaul, Molodezhnaya str., 20
3KGBUZ "Regional Clinical Hospital of Emergency Medical Care", 656031, Barnaul, Komsomol av., 73
Keywords: дисциркуляторная энцефалопатия, дисфункция эндотелия, когнитивные нарушения, dyscirculatory encephalopathy, endothelial dysfunction, cognitive disorders
Abstract
The aim of the study was to examine of endothelial dysfunction markers in patients with dyscirculatory encephalopathy I-II stages. Material and methods. The study included 30 patients with dyscirculatory encephalopathy I-II stages. All the examinees underwent detection of endothelin-1, desquamated circulating endothelial cells and endothelial NO synthase levels in the blood, reflected endothelial damage. Results of investigation of 21 practically healthy people served as control. Results. Reliable increasing of endothelial dysfunction markers were detected at initial stage of dyscirculatory encephalopathy, aggravated with the progress of disease.
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