Supramolecular Systems for the Delivery of the Molecules of Medicinal Substances Based on Water-Soluble Plant Metabolites. Physicochemical, Pharmacological Properties and the Features of Mechanochemical Preparation
A. V. DUSHKIN1, E. S. METELEVA1, T. G. TOLSTIKOVA2, M. V. KHVOSTOV2,3, N. E. POLYAKOV1,4, N. Z. LYAKHOV1
1Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
2N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
3Novosibirsk State University, Novosibirsk, Russia
4Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia
Keywords: системы доставки лекарств, механохимия, полисахариды, арабиногалактан, глицирризиновая кислота, сапонины, везикулярные системы, межмолекулярные комплексы, мембранная проницаемость, фармакокинетические характеристики, биодоступность, токсичность, фармакологическое действие, drug delivery systems, mechanochemistry, polysaccharides, arabinogalactan, glycyrrhizic acid, saponins, vesicular systems, intermolecular complexes, membrane permeability, pharmacokinetic characteristics, bioavailability, toxicity, pharmacological action
Pages: 206-216
Abstract
A brief review summarizes the results of integrated pharmacological and physicochemical studies carried out in the Russian Academy of Sciences, focused on the supramolecular systems for the delivery of the molecules of medicinal substances based on water-soluble plant metabolites - polysaccharides and glycyrrhizic acid, as well as its derivatives. The promising potential of the development of medicines, dietary supplements and plant protection products of increased efficiency and safety is shown. The advantages of the solid-phase mechanochemical technology for obtaining water-soluble compositions of poorly soluble drugs are demonstrated.
DOI: 10.15372/CSD2019129
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