FACTORS AFFECTING BONE REMODELING IN PATIENTS WITH HODGKIN’S LYMPHOMA (REVIEW)
Mariya Sergeevna VOYTKO1, Tatyana Ivanovna POSPELOVA1, Vadim Valerievich KLIMONTOV1,2, Elena Viktorovna MEZIT1
1Novosibirsk State Medical University of Minzdrav of Russia
2Research Institute of Clinical and Experimental Lymphology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Keywords: лимфома Ходжкина, минеральная плотность костной ткани, остеопороз, денситометрия, двухэнергетическая рентгеновская абсорбциометрия, Hodgkin’s lymphoma, bone mineral density, BMD, osteoporosis, dual-energy X-ray absorptiometry, dual X-ray absorptometry
Abstract
Hodgkin’s lymphoma is considered a potentially curable disease. Chemotherapy-based salvage regimens can achieve responses in 90 % of patients with Hodgkin’s lymphoma. The possibility of achieving persistent disease-free survival poses a problem of ensuring a satisfactory quality of life and preventing the long-term consequences of antitumor therapy. One of those consequences may be a change in bone mineral density. Currently, a number of researchers have established that the risk of osteoporosis and osteopenia is highest in patients with Hodgkin’s lymphoma as compared to patients with other lymphoproliferative disorders. The decrease in bone mineral density can be associated with polychemotherapy including various combinations of cytostatic drugs and glucocorticoids, hypogonadism caused by toxic effects of radiotherapy and chemotherapy, tumor process, low physical activity and other factors. The high importance of the problem of osteoporosis is determined from social consequences - fractures of the vertebral bodies and fractures of the peripheral skeleton. That leads to economic risks in the health care area and causing a high level of disability. The aim of the study was to reveal the main regularities of bone remodeling in patients with Hodgkin’s lymphoma.
|
