INFLUENCE OF PRIMARY POSTERIOR CAPSULOREXIS ON THE ACTIVITY OF LOCAL INFLAMMATORY PROCESS AT FACOEMULSIFICATION OF COMPLICATED CATARACT ON THE BACKGROUND OF THE PSEUDOEXPHOLIATION SYNDROME
Elena Vladilenovna EGOROVA1, Olga Olegovna OBUKHOVA2, Olga Mikhaylovna GORBENKO2, Alya Petrovna SHVAYUK2, CHERNYKH1, Аleksandr Nikolaevich TRUNOV1,2
1The S.N. Fyodorov Eye Microsurgery Complex of Minzdrav of Russia, Novosibirsk branch
Valeriy Vyacheslavovich
2Research Institute of Experimental and Clinical Medicine
Keywords: осложненная катаракта, псевдоэксфолиативный синдром, задний капсулорексис, воспаление, цитокины, complicated cataract, pseudoexfoliation syndrome, posterior capsulorhexis, inflammation, cytokines
Abstract
Purpose: to study the activity of the local inflammatory process in patients with complicated cataracts with pseudoexfoliation syndrome before and after phacoemulsification with the primary posterior capsulorhexis. 54 patients (54 eyes) aged 50 to 92 years (76 ± 7.43) appealed for surgical treatment of complicated cataracts with pseudoexfoliation syndrome were examined. The concentration of IL-6, IL-10, MMP-9, TGF-β1 was determined in the tear fluid of patients before and on the 5th day of the postoperative period. It was established that the activity of local inflammatory process (high concentrations of IL-6 and MMP-9) is determined in patients with complicated cataracts with pseudoexfoliation syndrome. The identified increase in TGF-1 concentrations is a significant factor in the formation of the pseudoexfoliation material. It has been established that the use of a modified surgical technique in patients with pseudoexfoliation syndrome does not lead to activation of the local inflammation process
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