EXPERIMENTAL STUDY OF THE ACUTE TOXICITY OF THE ORAL FORM OF PEGYLATED INTERFERON О±2-b
Dmitriy Nikolaevich KINSHT1,2, Pavel Gennad’evich MADONOV1,2, Tatyana Sergeevna TARTYNOVA1, Alexey Alexandrovich CHURIN3, Eugeniy Yur’evich SHERSTOBOEV3
1Novosibirsk State Medical University of Minzdrav of Russia
2Siberian Center of Pharmacology and Biotechnology
3Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of RAS
Keywords: интерферон О±-2b, пегилирование, иммобилизация, острая токсичность, доклинические исследования, interferon О±-2b, pegylation, immobilization, acute toxicity, preclinical trials
Abstract
The aim of the study is to investigate the acute toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Material and methods. The preparation was orally administered to mice and rats at calculated therapeutic doses and doses exceeding them. Recorded parameters: animal death, general condition and behavior, weight of animals. Results and discussion. The drug has no toxic effect when administered orally. No macroscopic signs of gastric damage were found. The definition of LD is not possible.
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