METALLOPROTEINASE AND ATHEROSCLEROSIS
Ya.V. Polonskaya, Yu.I. Ragino
Institute of Internal and Preventive Medicine - Branch of Federal Research Institute of Cytology and Genetics of SB RAS, 630089, Novosibirsk, Boris Bogatkov str., 175/1
Keywords: Atherosclerosis, destructive matrix metalloproteinases, tissue inhibitors of metalloproteinases, atherosclerotic plaque
Abstract
The review presents modern data on matrix metalloproteinases, their activators and inhibitors, as well as the results of numerous experimental and clinical studies of blood levels of these destructive enzymes in atherosclerosis, cardiovascular diseases and their complications, and discusses the mechanisms of action of metalloproteinases that lead to destabilization and rupture of atherosclerotic plaques.
|
