ATRIAL FIBRILLATION: PREVALENCE AND CROSS-SECTIONAL DETERMINANTS IN NOVOSIBIRSK POPULATION (HAPIEE COHORT, 9255 PARTICIPANTS)
M. Shapkina1, A. Ryabikov1, E. Voronina1, E. Mazdorova1, L. Sherbakova1, M. Bobak2, S. Malyutina1
1FSBSE В«Scientific Research institute of therapy and preventive medicine», Novosibirsk, Russia
2University of London, London, United Kingdom
Keywords: фибрилляция предсердий, распространенность, детерминанты, артериальная гипертензия, atrial fibrillation, the prevalence, determinants, hypertension, cross-sectional study
Abstract
Objectives: to investigate the prevalence and determinants of AF in cross-sectional study in a population sample 45-69 age (Novosibirsk). Materials and methods: a random population sample of men and women 45-69 years old (y. o.) (n=9360) was examined in Novosibirsk (project HAPIEE). We used standard epidemiological methods. As optional study ECG was registered participants and estimated by Minnesota code (n=9255). They were included for current analysis (grant RSF 14-45-0030). Results: in studied population sample the prevalence of AF was 1.6% (1.1% in women and 2.1% in men). The frequency of AF increased with age: from 0.3% in age group of 45-49 y. o. in both sexes to 4.0% in men and 2.8% in women in the oldest age group (65-69 y. o.), p<0.001. In unadjusted analysis, in men AF was associated with elder age, heart rate (HR) (р<0,001), diastolic blood pressure (р=0,003), body mass index (BMI) (р<0,001), presence of cardiovascular disease (CVD), hypertension (HT) (р<0,001) and diabetes mellitus (DM) (р=0,002). When we have compared laboratory parameters, the patients with AF had lower level of total cholesterol (TC) (р=0,001), low-density lipoprotein cholesterol (LDL-C) (р=0,005) and higher level of gamma-glutamyltranspeptidase (GGT) (p <0.001). The significant difference of alcohol consumption measures in relation to AF we did not identified in population sample. In women were similar results in the studied risk factors and cardiometabolic diseases. In multivariate regression, AF in men was positively associated with age, HR, BMI (p<0.001) and negatively related to level of triglycerides (p=0.019) and LDL-C level (p=0.001). Women had a positive association of AF with age, HR, BMI (p<0.001), GGT (p=0.002) and negative - to LDL-C level (p<0.001). Conclusions: in a population sample 45-69 y. o. of Novosibirsk the prevalence of AF was 1.6%, which is close to indicators in other populations. Determinants of AF were CVD, HT, DM, HR, BMI, increasing age (for both sexes) and GGT level in women. We did not find the direct relationship between AF and the atherogenic lipid profile; these results are likely to be associated with the modulating contribution of cardiometabolic factors.
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