THE ROLE OF IL1О’ CANDIDATE GENE POLYMORPHISMS IN THE OCCURRENCE OF MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE IN PATIENTS WITH CORONARY ARTERY DISEASE
O.L. Barbarash, J.V. Bairakova, A.V. Ponasenko, M.V. Khutornaya, A.A. Kuzmina, Y.V. Kazachek, L.S. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo
Keywords: инфаркт миокарда, мультифокальный атеросклероз, интерлейкин , мультифокальный атеросклероз, интерлейкин - IL1ОІ полиморфные сайты гена IL1ОІ rs1143634, rs16944, myocardial infarction, multivessel coronary artery disease, interleukin - IL1ОІ gene polymorphic sites IL1ОІ rs1143634
Abstract
Objective: To evaluate the contribution of IL1β gene polymorphisms rs1143634 and rs16944 in the development of myocardial infarction (MI) and multivessel coronary artery disease in patients with CAD. Material and Methods: 303 patients with stable coronary artery disease were included in the study. Serum IL1β levels were measured with commercial kits (Bender MedSystems, Austria). TaqMan genotyping assays were performed in 96-well plate. Results: Women, who were homozygous carriers of the IL-1β rs1143634 G major allele, had a 4-fold decreased risk of developing multivessel coronary artery disease (p = 0.046) as well as a 2-fold decreased risk of myocardial infarction (p = 0.0198). The variable site of the IL1β rs1143634 was significantly (p = 0.0025) associated with a reduced risk of MI according to the dominant inheritance pattern (OR = 0.48, 95% CI = 0.29- 0.77), and rs16944 - with a five-fold increased risk (p = 0.0022) according to the co-dominant model (OR = 5.12, 95% CI = 1.82-14.42). The risk of myocardial infarction in men, who were homozygous carriers of the IL1β rs16944 T minor allele, was six times higher than that in women (p = 0.0093). The AC haplotype (rs1143634- rs16944) was associated with a 2-fold reduced risk of myocardial infarction and PICS (OR = 0.49, 95% CI = 0.29-0.81, p <0.0059), with the most pronounced effects in the age of 65 years (p = 0.0031). However, the GT haplotype rs1143634-rs16944 in younger patients (<65 years) was associated with the development of myocardial infarction (p = 0.0074). Conclusion: Genetic markers should be taken into consideration as an independent predictors of myocardial infarction and multivessel coronary artery disease.
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