2-methylpyridinium 5-(2,4-dinitrophenyl)-6-oxo-2-thioxo-1,2,3,6-tetrahydropyrimidin-4-olate: synthesis, crystal structure, and biological evaluation
G. Mangaiyarkarasi, G. Sridevi, P. P. Devi, D. Kalaivani
Seethalakshmi Ramaswami College, Tamil Nadu, India
Keywords: carbon-bonded anionic sigma complex, 2-thiobarbituric acid, 1-chloro-2,4-dinitrobenzene, single crystal X-ray diffraction studies, anticonvulsant activity, maximal electroshock method
Abstract
The titled complex is synthesized from the ethanolic solutions of 1-chloro-2,4-dinitrobenzene, 2-thiobarbituric acid, and 2-methylpyridine and characterized by spectral and elemental analyses. The single crystal X-ray diffraction results for the complex are compatible with the spectral observations. The titled complex exhibits anticonvulsant activity and reduces all phases of convulsion even at a low dosage. Acute toxicity studies of the complex are performed to understand the safer dose concentration for clinical trials.
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