GENDER FEATURES OF NONALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH METABOLIC SYNDROME
A.B. Krivocheev, A.D. Kuimov, K.V. Popov, P.A. Bogoriynova, M.A. Kondratova, T.A. Tuguleva, S.K. Gubanova
Novosibirsk state medical university Russian Ministry of Health, 630091 Novosibirsk, Krasny Prospeсt, 52
Keywords: неалкогольная жировая болезнь печени, метаболический синдром, мужчины, женщины, дислипидемия, инсулинорезистентность, Nonalcoholic fatty liver disease, metabolic syndrome, men, women, dyslipidemia, insulin resistance
Abstract
Evaluation of clinical course and metabolic disorders in men and women with non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS). Was investigated 164 patients with NAFLD, including 103 men and 61 women. In comparative terms we studied clinical manifestations of NAFLD. All patients NAFLD was verified for the first time. We studied the functional state of the liver function, lipid, carbohydrate and insulin resistance. The study involved 164 patients with NAFLD, including 103 men aged 29 to 64 years and 61 women aged from 44 to 63 years. All the women were examined in a phase of physiological menopause. Patients were divided into 2 groups. In Group 1 included 124 patients with diagnostic criteria for MS, Group 2 consisted of 40 patients without MS. Violations evaluated differentially in men and women. NAFLD is found in most patients with MS in the background. However, a cluster of factors constituting MS significantly more pronounced in men. Main patofi-physiologically factors contributing to the formation of NAFLD, namely TS and-Disley-epidemic appeared to be more significant in men. Perhaps this may be due to bo-Lee early development of liver steatosis in males and younger age compared to women. NAFLD is diagnosed more often in men.
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