PREDICTORS OF CORONARY ATHEROSCLEROSIS IN MEN WITH METABOLIC SYNDROME
D.M. Rudakova1, A.A. Efremushkina2
1Altai State Medical University, Barnaul
2KGBUZ Altai Regional Clinical Hospital, Barnaul
Keywords: метаболический синдром, коронарных сосудов сердца, маркеры воспаления, апелин, metabolic syndrome, coronary heart, inflammation markers, apelin
Abstract
Aim: The one of the main directions in the prevention of coronary heart disease (CHD) is to improve the technology for the detection of high cardiovascular risk persons for purpose of preventive measures aimed at the prevention of the disease. Object: To determine the most significant collection of risk factors for coronary atherosclerosis in men with metabolic syndrome. Material and Methods: The study involved 82 male patients with metabolic syndrome, divided into 2 groups of CHD after verification. All the patients were determined profile of lipid and carbohydrate metabolism and pro-inflammatory cytokines and adipokines. Results: The patients in the presence of coronary artery disease and MS have higher levels of CRP (p = 0.001 ) , IL -1 ( p = 0.017 ) , IL -6 ( p = 0.001) FNO (p = 0.001 ) , E - selectin ( p = 0.001 ) , and the patients without coronary artery disease have higher apelin levels. Conclusion: A multi-dimensional mathematical model created by us and based on the method of multivariate logistic regression analysis could allow to predict the presence of coronary atherosclerosis in patients with MS based on the analysis of the set of predictors obtained.
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