CHARACTERIZATION AND CYTOTOXIC PROPERTY OF A LADDER-LIKE POLYMERIC SILVER(I) COMPLEX DERIVED FROM 3-AMINOPYRAZINE-2-CARBOXYLIC ACID
G.-S. Li, H.-L. Zhang
Zhengzhou University of Light Industry, Zhengzhou 450002, P. R. China
Keywords: silver complex, polymeric complex, 3-aminopyrazine-2-carboxylate, crystal structure, cytotoxicity
Abstract
A novel ladder-like polymeric silver(I) complex, [Ag2L2] n ×2 n H2O, where L is 3-aminopyrazine-2-carboxylate, was obtained by the reaction of 3-aminopyrazine-2-carboxylic acid and silver oxide in aqueous ammonia. The complex was characterized by elemental analysis, IR spectra and single crystal X-ray determination. The smallest repeat unit contains a [Ag2L2] moiety and two water molecules. The Ag⋯Ag distance is 3.176(1) mmol. Each Ag atom is in a Y-shaped coordination, with one carboxylate O and two pyrazine N atoms from two ligands. In the crystal structure of the complex, the dinuclear silver moieties are linked through 3-aminopyrazine-2-carboxylate ligands, to form 1D ladder-like chain along the b axis. The water molecules are linked to the silver chain through hydrogen bonds. There are p⋯p interactions between the chains. The complex showed effective cytotoxic property on human lung cancer cell line A549.
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