CRYSTAL STRUCTURE AND ANTITUMOR ACTIVITIES OF A DINUCLEAR COBALT(II) COMPLEX BASED ON meso-1,2,3,4-TETRA(1H-BENZO[d]IMIDAZOL-2-YL)BUTANE
Q.-W. Huang1, S.-X. Wang2, S.-G. Liu1, W.-Y. Su1, G.-B. Li1, Y.-M. He1
1Lingnan Normal University, Guangdong, Zhanjiang, P. R. China
2Medical School of Shenzhen, Shenzhen, P. R. China
Keywords: benzimidazole, cobalt complex, crystal structure, antitumor activities
Abstract
The [Co2(tbb)Cl4]×4DMF complex, where tbb is meso -1,2,3,4-tetra(1H-benzo[ d ]imidazol-2-yl)butane, is synthesized and characterized by single crystal X-ray diffraction. For the complex: C44H54Co2Cl4N12O4, Mr = 1074.65, monoclinic crystal system, space group P 21/ n , a = 9.2350(13) Å, b = 11.3566(15) Å, c = 23.879(3) Å, b = 90.547(2)°, V = 2504.3(6) Å3, Z = 2, Dc = 1.425 g/cm3, l = 0.71073 Å, m(Mo K a) = 0.929 mm-1, F (000) = 1112, S = 1.047, R = 0.0765, and wR = 0.2110 for 13668 observed reflections with I > 2 s( I ) . It is a neutral dinuclear complex. One meso -1,2,3,4-tetra(1H-benzo[ d ]imidazol-2-yl)butane coordinates two cobalt(II) ions. Each cobalt(II) ion is formed by two tbb nitrogen atoms and two chloride ions. The antiproliferative activities of the complex are screened by MTT assay against Eca109 cancer cells. The complex exhibits inhibition on the growth of Eca109 cancer cells with IC50 of 22.1±6.7 mM after 48 h treatment. The cobalt complex has potential application in treatment of Eca109 cancer. CCDC 1015791.
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