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Chemistry for Sustainable Development

2015 year, number 5

Complexation of ОІ-Cyclodextrin and Hydroxypropyl-ОІ-Cyclodextrin with Biologically Active Compound Based on 1,2,4-Thiadiazole

M. A. BRUSNIKINA1, M. V. CHISLOV1, O. I. SILYUKOV1, T. V. VOLKOVA1, A. N. PROSHIN2 and I. V. TEREKHOVA1
1Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ul. Akademicheskaya 1, Ivanovo 153045 (Russia)
2Institute of Physiologically Active Substances, Russian Academy of Sciences, Severnyi Pr. 1, Chernogolovka 142432 (Russia)
Keywords: циклодекстрины, 1, 2, 4-тиадиазолы, супрамолекулярные комплексы, растворимость, cyclodextrins, 1, 2, 4-thiadiazoles, supramolecular complexes, solubility

Abstract

Complexation of the derivative of 1,2,4-thiadiazole, exhibiting biological activity in therapy of Alzheimer's disease, with β-and hydroxypropyl-β-cyclodextrin was studied using the methods of isothermal saturation and UV spectroscopy in phosphate buffer solution (рН 7.4). It was shown that the formation of the complexes with stoichiometric composition 1 : 1 involves the inclusion of the benzene ring of guest molecule, which is held in the macrocyclic cavity of the host mainly by hydrophobic interactions. Hydroxypropyl-β-cyclodextrin exhibits higher complex-forming and solubilizing capacity in comparison with β-cyclodextrin with respect to the biologically active compound.