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Chemistry for Sustainable Development

2015 year, number 5

Hypolipidemic Effect of the Phytocompositions of Gynostemma pentaphyllum and Polysaccharide Arabinogalactan Prepared by Means of Mechanochemistry

E. S. PETROVA1,2, M. V. KHRAPOVA3, L. P. SUNTSOVA1, A. V. DUSHKIN1, E. I. VERESHCHAGIN4 and M. I. DUSHKIN2
1Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Ul. Kutateladze 18, Novosibirsk 630128 (Russia)
2Research Institute of Therapy and Prophylactic Medicine, Ul. Borisa Bogatkova 175/1, Novosibirsk 630089 (Russia)
3Research Institute of Physiology and Fundamental Medicine, Ul. Timakova 4, Novosibirsk 630117 (Russia)
4Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Krasnyi Prospekt 52, Novosibirsk 630091 (Russia)
Keywords: гиностемма пятилистная, механохимическая обработка, гиполипидемический эффект, фитокомпозиция, арабиногалактан, Gynostemma pentaphyllum, mechanochemcial treatment, hypolipidemic effect, phytocomposition, arabinogalactan

Abstract

Phytocompositions based on Gynostemma pentaphyllum (GP) and arabinogalactan (AG) were obtained by means of mechanochemical activation. The addition of AG into the mixture under treatment promotes the formation of water-soluble intermolecular complexes with increased biological assimilability of biologically active substances, and increases the solubility of the phytocomposition in water. In all activated samples, the extractability of saponins from GP increases by a factor of 3.4-4.7. The hypolipidemic action of GP-based samples was demonstrated for the hyperlipidemia model in mice after single intra-abdominal introduction of poloxamer-407. The introduction of GP/AG composition at a ratio of 1 : 2 (by mass) caused a decrease in the level of cholesterol and triglycerides by 56 and 63 %, respectively. For the model of high-lipid diet for rats, the hypolipidemic action of the phytocomposition under investigation was confirmed: the level of triglycerides and cholesterol decreased by 46 and 29 %, respectively, in comparison with reference animals kept to a fatty diet.