Siberian Opisthorchosis. Biology, Distribution and Development of New Preparations for Its Treatment
V. A. MORDVINOV1, M. YU. PAKHARUKOVA1, A. V. KATOKHIN1, A. V. DUSHKIN2, YU. S. CHISTYACHENKO2, A. I. BELOUSOV1, M. V. KHVOSTOV3, N. A. ZHUKOVA3, S. S. KHALIKOV4, T. G. TOLSTIKOVA3 and N. Z. LYAKHOV2
1Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Akademika Lavrenyeva 10, Novosibirsk 630090 (Russia)
2Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Ul. Kutateladze 18, Novosibirsk 630128 (Russia)
3Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Pr. Akademika Lavrentyeva 9, Novosibirsk 630090 (Russia)
4Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Ul. Vavilova 28, Moscow 119991 (Russia)
Keywords: описторхоз, празиквантел, альбендазол, механохимия, межмолекулярные комплексы, полисахариды, арабиногалактан, растворимость, opisthorchosis, prasiquantel, albendazol, mechanochemistry, intermoloecular complexes, polysaccharides, arabinogalactan, solubility
Abstract
Opisthorchosis is a widespread helminthiasis at the territory of Europe and Asia, accompanied by such complications as gallbladder dysfunction, cholecystitis, cholangitis, hepatic abscess, and cholelithiasis. Prasiquantel, a preparation used at present to treat opisthorchosis, is insufficiently effective. Mechanochemical preparation of the intermolecular complexes of antihelminthic agent albendazol with polysaccharide arabinogalactan is described. The activity of these complexes against opisthorchosis was studied
in vivo in laboratory animals. The possibility of the development of new medical products based on albendazol exceeding prasiquantel is demonstrated.
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