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Chemistry for Sustainable Development

2015 year, number 5

Physicochemical Approaches to the Studies of New Systems of Drug Delivery Based on Natural Polysaccharides

O. YU. SELYUTINA1,2, N. E. POLYAKOV1, E. S. METELEVA3 and A. V. DUSHKIN3
1Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, Ul. Institutskaya 3, Novosibirsk 630090 (Russia)
2Novosibirsk State University, Ul. Pirogova 2, Novosibirsk 630090 (Russia)
3Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, Ul. Kutateladze 18, Novosibirsk 630128 (Russia)
Keywords: системы доставки лекарств, комплексы включения, полисахариды, арабиногалактан, глицирризиновая кислота, ядерный магнитный резонанс, drug delivery systems, inclusion complexes, polysaccharides, arabinogalactan, glycyrrhizic acid, nuclear magnetic resonance

Abstract

The use of natural oligosaccharides and polysaccharides as complexing agents for the delivery of pharmaceutical substances causes a substantial increase in their therapeutic activity and storage stability, and reduces side effects. The use of modern physical methods to study molecular processes allows obtaining unique information on the structure, dynamics and physicochemical properties of supramolecular inclusion complexes of pharmaceutical compounds. The review illustrates the possibilities of physical methods in studying the means of drug delivery in the solid state and in solutions, and in establishing the mechanisms of increasing bioavailability of pharmaceutical compounds within inclusion complexes.