CRYSTALLIZATION OF CALCIUM OXALATE MONOHYDRATE IN THE PRESENCE OF AMINO ACIDS: FEATURES AND REGULARITIES
O. A. Golovanova1, Yu. O. Punin2, A. R. Izatulina2, V. V. Korol'kov1
1Omsk State University, Omsk, Russia
2St. Petersburg State University, St. Petersburg, Russia
Keywords: kidney stones, crystallization and nucleation kinetics, protein constituent, amino acid composition, calcium oxalate monohydrate
Abstract
The protein composition of the organic component of kidney stones and the effect of major amino acids of the physiological solution on the crystallization process of calcium oxalate is studied in the work. By means of a complex technique the protein compounds are analyzed in 40 samples of kidney stones obtained by both direct surgical operations and distant lithotripsy. A strong and selective concentration of amino acids in different stones in comparison with the physiological fluids forming them is established. Nucleation processes and the crystallization kinetics of calcium oxalate monohydrate are studied in the model solutions without impurities and with additions of 13 amino acids. Different amino acids can both inhibit and promote these processes depending on the acid structure.
|
